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Characterization of the role of copper transporting ATPase, ATP7B (Wilsons disease protein), in...
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Characterization of the role of copper transporting ATPase, ATP7B (Wilsons disease protein), in copper homeostasis.
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http://www.ohsu.edu/xd/education/library/services/theses-dissertations/rights-statement.cfm
Title
Characterization
of the
role
of
copper
transporting
ATPase
,
ATP7B
(Wilsons
disease
protein)
, in
copper
homeostasis
.
Creator.PersonalName
Bartee
,
Mee
Y
.
Thesis.Degree
Ph.D.
Thesis.Major
Biochemistry and Molecular Biology
Thesis.DateDegreeAwarded
September
2008
Institution
Oregon Health & Science University
School
School of Medicine
Department
Dept. of Biochemistry and Molecular Biology
Thesis.Chair
Rotwein, Peter S.
Thesis.Committee
Lutsenko, Svetlana V.
Farrens, David L.
Enns, Caroline A.
Koeller, David M.
Subject.MeSH
Copper -- physiology
Adenosine Triphosphatases -- physiology
Protein Transport -- physiology
Cell Polarity -- physiology
Call Number
Q171 M481 2008
Description.Abstract
All
organisms
must
implement
a
method
of
copper
regulation
in
order
to
utilize
yet
protect
the
cell
from
cytotoxic
effects
.
ATP7B
, a
P-type
ATPase
,
is
a
copper
transporter
expressed
in
human
cells
that
regulates
the
delivery
of
copper
to
proteins
in the
biosynthetic
pathway
and
maintains
the
intracellular
concentration
of
copper
.
Copper
homeostasis
is
preserved
through
several
mechanisms
. The
expression
of a
smaller
protein
product
in the
kidney
, as
opposed
to
full
length
ATP7B
in the
liver
,
leads
to the
different
trafficking
responses
to
elevated
copper
,
no
trafficking
in the
former
and
vesicular
localization
in the
latter
.
Spatial
control
of
ATP7B
localization
at the
TGN
,
vesicles
, or
canalicular
membrane
is
dependent
on the
copper
status
of the
cell
,
controlling
the
ratio
of
intracellular
copper
to that
destined
for
export
.
Phosphorylation
of
ATP7B
in the
serine
rich
region
between
MBD3
and
4
is
also
important
in the
regulation
of
ATP7B
intracellular
localization
. The
many
mechanisms
utilized
by
ATP7B
for
regulation
of
copper
suggest
there
is
a
delicate
balance
between
copper
necessity
and
excess
. In
addition
to
direct
regulation
of
copper
homeostasis
through
ATP7B
,
other
interacting
proteins
such
as
ceruloplasmin
may
play
a
role
in
copper
maintenance
.
Language
eng
Type
Text
Format.Use
Needs Adobe Acrobat to view
Format.FileSize
4965063 Bytes
OCLC number
299054444
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