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The role of adrenergic receptors in the potential reconsolidation of a cocaine conditioned place...
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The role of adrenergic receptors in the potential reconsolidation of a cocaine conditioned place preference.
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http://www.ohsu.edu/xd/education/library/services/theses-dissertations/rights-statement.cfm
Title
The
role
of
adrenergic
receptors
in the
potential
reconsolidation
of a
cocaine
conditioned
place
preference
.
Creator.PersonalName
Bernardi
,
Rick
E
.
Thesis.Degree
Ph.D.
Thesis.Major
Behavioral Neuroscience
Thesis.DateDegreeAwarded
September
2009
Institution
Oregon Health & Science University
School
School of Medicine
Department
Dept. of Behavioral Neuroscience
Thesis.Advisor/Mentor
Berger, Stephen Paul
Lattal, Kennon Matthew
Thesis.Committee
Cunningham, Christopher L.
Mark, Gregory P.
Kozell, Laura B.
Subject.MeSH
Receptors, Adrenergic
Cocaine
Propranolol
Amygdala
Call Number
Q171 B522 2009
Description.Abstract
The
disruption
of
memory
retention
following
retrieval
has been
proposed
to be
due
to the
impairment
of a
memory
reconsolidation
process
.
Deficits
in
behavior
attributed
to
reconsolidation
have been
demonstrated
in a
number
of
learning
paradigms
in
animal
models
,
including
the
associative
learning
that
occurs
between
neutral
stimuli
and
drugs
of
abuse
.
Because
drug-associated
stimuli
can
be a
major
factor
in the
persistence
of
addiction
in
humans
,
targeting
potential
reconsolidation
mechanisms
has been
suggested
as a
potential
target
of
pharmacotherapies
aimed
at
dampening
the
powerful
control
of these
stimuli
over
behavior
. To that
end
,
several
studies
have
demonstrated
impairment
of
reconsolidation
as a
means
to
reduce
drug
cue-mediated
behaviors
in
animals
using
a
variety
of
pharmacological
treatments
. The
focus
of this
dissertation
was to
examine
the
role
of the
noradrenergic
system
as a
potential
mediator
of the
reconsolidation
of
drug
memories
using
the
conditioned
place
preference
(CPP)
paradigm
using
adrenergic
receptor
(AR)
antagonists
administered
systemically
and
site-specifically
into the
basolateral
amygdala
, a
brain
region
previously
demonstrated
to
mediate
reconsolidation
. The
non-specific
β1/β2-AR
antagonist
,
propranolol
,
when
systemically
administered
following
an
initial
test
of
cocaine
CPP
,
attenuated
preference
during
a
subsequent
test
. This
result
was then
replicated
with
systemic
adminstration
of the
β2-AR
antagonist
ICI
118,551
, but not the
β1-AR
antagonist
betaxolol
,
demonstrating
a
β2-specific
mechanism
of the
effect
of
propranolol
.
Furthermore
, the
α1-adrenergic
antagonist
prazosin
,
when
administered
post-test
, also
attenuated
a
subsequent
preference
.
Language
eng
Type
Text
Format.Use
Needs Adobe Acrobat to view
Format.FileSize
756472 Bytes
OCLC number
465509055
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