Effect of intravenous recombinant tissue platminogen activator on ischemic stroke in a mouse model of middle cerebral artery occulusion measured by optical micro-angiography.

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Rights	http://www.ohsu.edu/xd/education/library/services/theses-dissertations/rights-statement.cfm
Title	Effect of intravenous recombinant tissue platminogen activator on ischemic stroke in a mouse model of middle cerebral artery occulusion measured by optical micro-angiography.
Creator.PersonalName	Hurst, Sawan
Thesis.Degree	M.S.
Thesis.Major	Biomedical Informatics
Thesis.DateDegreeAwarded	August 2010
Institution	Oregon Health & Science University
School	School of Medicine
Department	Dept. of Biomedical Engineering
Thesis.Advisor/Mentor	Wang, Ruikang K.
Thesis.Committee	Gruber, András S. Alkayed, Nabil J. McCarty, Owen J. T.
Subject.LCSH	Cerebral arteries Angiography
Subject.Keyword	OMAG; Optical micro-angography; MCAO; Middle cerebral artery occlusion; tPA
Subject.MeSH	Infarction, Middle Cerebral Artery Tissue Plasminogen Activator Cerebral Angiography
Call Number	Q 183.5.OGISE H966 2010
Description.Abstract	We have developed a new optical micro-angiography (OMAG) imaging technique that is capable of resolving 3D distribution of dynamic blood perfusion at a 10 µm resolution within icrocirculatory beds in vivo. The imaging contrast of blood perfusion is based on endogenous light scattering from moving blood cells within vessels, thus no exogenous contrast agents are necessary. The technique effectively separates the moving and static scattering elements within tissue to achieve high resolution images of blood flow, mapped into the 3-D optically sectioned tissue beds, at speeds that allow for perfusion assessment in vivo. We used OMAG to visualize the cerebral microcirculation of adult living mice through the intact cranium. These measurements would be difficult, if not impossible, with other optical imaging techniques. The purpose of this study is to validate OMAG as a method and assess its potential applications in the studies of cerebrovascular perfusion during and after induced stroke in treated mice. To do this we treated animals with tissue plasminogen activator (tPA) or vehicle and then used OMAG to obtain real time images to compare the mechanisms of reperfusion of each treatment. From these images tPA is shown to greatly effect the reperfusion. It is shown that tPA increases the reperfusion rate and blood volume into the affected hemisphere which in turn increases the animals’ behavior and survival chances.
Language	eng
Type	Text
Format.Use	Needs Adobe Acrobat to view
Format.FileSize	24740043 Bytes
OCLC number	696018255

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Effect of intravenous recombinant tissue platminogen activator on ischemic stroke in a mouse model of middle cerebral artery occulusion measured by optical micro-angiography.

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