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The genomic response to song and the representation of complex sounds in the auditory system of...
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The genomic response to song and the representation of complex sounds in the auditory system of zebra finches
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http://www.ohsu.edu/xd/education/library/services/theses-dissertations/rights-statement.cfm
Title
The
genomic
response
to
song
and the
representation
of
complex
sounds
in the
auditory
system
of
zebra
finches
Creator.PersonalName
Velho
,
Tarciso
Andre
Ferreira
Thesis.Degree
Ph.D.
Thesis.Major
Neuroscience
Thesis.DateDegreeAwarded
June
2008
Institution
Oregon Health & Science University
School
School of Medicine
Division
Neuroscience Graduate Program
Thesis.Advisor/Mentor
Mello, Claudio V.
Thesis.Committee
Bell, Curtis C.
Duvoisin, Robert M.
Subject.MeSH
Songbirds
Gene Expression
Sound
Call Number
Q171 V436 2008
Description.Abstract
The
consolidation
of
long-lasting
sensory
memories
requires
the
activation
of
gene
expression
programs
.
However
, to
fully
understand
the
contribution
of
genomic
events
necessary
for
sensory
learning
,
it
is
necessary
to
characterize
the
components
involved
in this
response
, their
induction
kinetics
, and the
possible
functional
interactions
among
individual
components
.
Birdsong
represents
one
of the
best
natural
behaviors
to
study
gene
expression
induced
by
auditory
stimulation
in
awake
,
freely
behaving
animals
. The
present
work
addresses
the
properties
and
functional
consequences
of the
genomic
response
to
birdsong
in
zebra
finches
(Taeniopygia
guttata)
, with a
specific
focus
on the
caudomedial
nidopallium
(NCM)
, a
cortical-like
auditory
area
involved
in
song
auditory
processing
and
memorization
.
We
found
that
song
induces
a
well-orchestrated
cascade
of
gene
expression
that
includes
early
and
late
genes
.
Early
genes
are
co-expressed
by
NCM
neurons
and their
induction
is
regulated
by the
mitogen-activated
protein
(MAP)
kinase
pathway
. In
addition
,
we
also
found
that the
induction
of
early
genes
is
locally
modulated
by
norepinephrine
.
We
have also
identified
two
late
genes
,
syn2
and
syn3
,
whose
induction
is
repressed
by
early
song-induced
proteins
genes
in
NCM
.
Functionally
,
we
show
that
blockade
of this
response
by
α-adrenergic
antagonists
disrupts
the
long-term
maintenance
of
long-lasting
neuronal
changes
triggered
by
song
.
Finally
,
we
show
that the
pattern
of
early
song-induce
gene
expression
in
NCM
is
stimulus
dependent
. These
patterns
also
indicate
the
existence
of
functional
subdomains
of
more
or
less
selectivity
towards
conspecific
songs
.
Overall
, these
results
help
us
understand
the
functional
significance
of the
genomic
response
to
song
and the
functional
organization
of
sound
representation
in a
higher
order
auditory
area
of the
songbird
brain
.
Language
eng
Type
Text
Format.Use
Needs Adobe Acrobat to view
Format.FileSize
3558744 Bytes
OCLC number
298462775
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